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Difference between aged and cancer mitochondria. Legend: Comparison of the differences between mitochondria from normal cells and mitochondria from aged and cancer cells. Changes in mitochondrial function lead to changes that can be bidirectional (arrows). Abbreviations: UPRmt, mitochondrial unfolded protein response; ATP, adenosine triphosphate; TCA, tricarboxylic acid; ROS, reactive oxygen species; DAMP, danger associated molecular pattern.
