Table 1.
Study population baseline data. Data are presented with median values (interquartile range, IQR) or mean values (±standard deviation) for continuous variables and for categorical variables with absolute numbers and corresponding percentages.
| Study Population (n = 338) |
Low-TPP (n = 256) |
High-TPP (n = 82) |
p-Value | |
|---|---|---|---|---|
| Age, years | 63.1 (±10.1) | 62.0 (±10.4) | 66.6 (±8.1) | <0.001 |
| Female, n (%) | 144 (42.6) | 122 (47.7) | 22 (26.8) | <0.001 |
| Body mass index, kg/m2 | 25.3 (4.7) | 25.2 (4.4) | 26.2 (4.3) | n.s. |
| Hypertension, n (%) | 218 (64.5) | 154 (60.2) | 64 (78.0) | 0.003 |
| Family history for CVD, n (%) | 78 (23.1) | 61 (23.8) | 17 (20.7) | n.s. |
| Smoking, pack years | 12.3 (±19.6) | 11.4 (±19.06) | 15.2 (±21.8) | n.s. |
| Hyperlipidemia, n (%) | 295 (87.3) | 224 (87.5) | 71 (86.6) | n.s. |
| Diabetes mellitus, n (%) | 47 (13.9) | 36 (14.1) | 11 (13.4) | n.s. |
| hsCRP, mg/dL | 0.17 (0.29) | 0.17 (0.32) | 0.17 (0.27) | n.s. |
| sP-selectin, µg/mL | 40.0 (24) | 41.0 (25.1) | 36.3 (20) | n.s. |
| Total cholesterol, mg/dL | 196.5 (±46.4) | 198 (±48.8) | 189 (±37.5) | n.s. |
| LDL-cholesterol, mg/dL | 115.0 (55.75) | 119 (59.0) | 106 (46.0) | n.s. |
| HDL-cholesterol, mg/dL | 58.0 (26.75) | 58.0 (28.0) | 58.0 (26.0) | n.s. |
| Triglyceride mg/dL | 128.0 (85.0) | 132 (88) | 118 (76) | n.s. |
| eGFR, mL/min/1.73 m2 | 76.6 (±15.5) | 77.59 (±15.9) | 73.53 (±13.9) | n.s. |
| Antiplatelet therapy, n (%) | 157 (46.4) | 118 (46.1) | 39 (47.6) | n.s. |
| Lipid lowering therapy | 192 (56.8) | 144 (56.3) | 48 (58.5) | n.s. |
| Antihypertensive therapy | 195 (57.7) | 139 (54.3) | 56 (68.3) | 0.02 |
| ESC SCORE | 3.0 (3.0) | 2.0 (3.0) | 4.0 (2.5) | <0.001 |
| CAD, n (%) | 106 (31.4) | 82 (32.0) | 24 (29.3) | n.s. |
| CRVD, n (%) | 34 (10.1) | 25 (9.8) | 9 (11.0) | n.s. |
| PAD, n (%) | 28 (8.3) | 20 (7.8) | 8 (9.8) | n.s. |
TPP—total plaque progression; CVD—cardiovascular disease; CAD—coronary artery disease; hsCRP—high-sensitivity C-reactive protein; LDL—low-density lipoprotein; sP-selectin—soluble P-selectin; HDL—high-density lipoprotein; eGFR—estimated glomerular filtration rate, ESC—European society of cardiology, CRVD—cerebrovascular disease, PAD—peripheral arterial disease, n.s.—not significant.