. Author manuscript; available in PMC: 2023 Oct 27.

Published in final edited form as: J Nat Prod. 2021 Aug 31;84(9):2486–2495. doi: 10.1021/acs.jnatprod.1c00501

Table 10.

AUC/dose values of matrine in the herbal mixture and pure compound using different routes of administration

Administration protocol	Matrine dosage (mg/kg)	C_max/Dose (ng/mL)/(mg/kg)	AUC_0-t /Dose (hr*ng/mL)/(mg/kg)
*Blood concentration*
500 mg/kg ATB IV	2.79	1408.3 ± 835.8	1830.0 ± 1241.2
100 mg/kg ATB Oral	0.56	25.9 ± 20.5	58.5 ± 32.7
500 mg/kg ATB Oral	2.79	19.3 ± 10.2	43.1 ± 21.3
4000 mg/kg ATB Oral	22.32	31.8 ± 10.6	164.1 ± 60.0
5 mg/kg KAC Oral	5.00	22.0 ± 7.4	46.9 ± 13.0
500 mg/kg ATB IP Day 1	2.79	292.4 ± 147.8	528.7 ± 200.9
500 mg/kg ATB IP Day 7	2.79	197.8 ± 144.1	592.0 ± 434.7
*Saliva concentration*
500 mg/kg ATB IP Day 7	2.79	1533.9 ± 823.5	952.8 ± 594.4