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. Author manuscript; available in PMC: 2023 Oct 27.
Published in final edited form as: J Nat Prod. 2021 Aug 31;84(9):2486–2495. doi: 10.1021/acs.jnatprod.1c00501

Table 6.

Pharmacokinetics parameters of ATB components after i.v. administration of 500 mg/kg ATB (n = 5)

Parameters Half-life
(hr)		 Cmax
(ng/mL)		 AUC0–24
(hr*ng/mL)		 AUC0–∞
(hr*ng/mL)		 V
(L/kg)		 CL
(L/hr/kg)		 MRT0–24
(hr)
Matrine 7.5 ± 3.3 3929.1 ± 2331.9 5113.1 ± 3467.8 5170.7 ± 3462.8 9.1 ± 6.6 0.8 ± 0.5 1.8 ± 0.5
Maackiain 4.9 ± 2.4 67.5 ± 38.6 68.9 ± 42.4 71.5 ± 43.2 4.1 ± 3.1 0.6 ± 0.2 3.0 ± 1.8
Dictamine 0.4 ± 0.2 34.0 ± 27.1 24.5 ± 16.4 24.8 ± 16.5 0.6 ± 0.4 0.9 ± 0.7 0.5 ± 0.1
Fraxinellone 5. 2 ± 2.0 34.3 ± 13.5 95.2 ± 9.4 166.8 ± 58.4 2.9 ± 0.3 0.4 ± 0.1 3.2 ± 0.4