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Pharmacokinetic parameters of ATB compounds after oral administration of 4000 mg/kg ATB (n = 5)
| Parameters | Tmax (hr) |
Cmax (ng/mL) |
AUC0–24 (hr*ng/mL) | AUC0–∞ (hr*ng/mL) | Half-life (hr) |
MRT0–24 (hr) |
|---|---|---|---|---|---|---|
| Matrine | 0.7 ± 0.6 | 709.1 ± 237.2 | 3667.7 ± 1340.4 | 5371.8 ± 1349.9 | 7.5 ± 2.8 | 4.5 ± 1.2 |
| Maackiain | 0.7 ± 0.6 | 16.4 ± 9.9 | 25.5 ± 15.3 | 27.5 ± 14.6 | 3.5 ± 1.0 | 3.6 ± 3.2 |
| Dictamine | 0.4 ± 0.3 | 4.2 ± 1.9 | 8.0 ± 3.8 | 9.4 ± 4.8 | 2.6 ± 2.0 | 3.6 ± 1.9 |
| Fraxinellone | 0.5 ± 0.3 | 4.7 ± 3.3 | 1.1 ± 1.5 | - | - | 0.4 ± 0.2 |
