. Author manuscript; available in PMC: 2023 Oct 27.

Published in final edited form as: J Nat Prod. 2021 Aug 31;84(9):2486–2495. doi: 10.1021/acs.jnatprod.1c00501

Table 9.

Pharmacokinetic parameters of ATB compounds after intraperitoneal administration of 500 mg/kg ATB once a day in seven days (n = 5).

Compound		T_max (hr)	C_max (ng/mL)	AUC_0–24 (hr*ng/mL)	AUC_0–∞ (hr*ng/mL)	Half-life (hr)	MRT_0–24 (hr)
Matrine	Day 1	0.2 ± 0.1	815.9 ± 412.4	1477.3 ± 561.3	1660.4 ± 508.8	7.3 ± 2.6	5.3 ± 0.8
Matrine	Day 7	0.5 ± 0.4	551.8 ± 402.0	1651.6 ± 1212.9	2254.0 ± 1862.3	8.2 ± 3.7	8.0 ± 3.2
Maackiain	Day 1	0.2 ± 0.1	15.6 ± 13.4	5.6 ± 5.6	-	-	0.3 ± 0.1
Maackiain	Day 7	0.6 ± 0.3	17.2 ± 3.7	47.4 ± 7.5^*	51.8 ± 7.5	2.2 ± 0.7	8.4 ± 1.5
Dictamine	Day 1	0.2 ± 0.1	1.9 ± 0.6	1.0 ± 0.5	-	-	0.4 ± 0.2
Dictamine	Day 7	0.5 ± 0.0*	3.8 ± 1.8	23.2 ± 5.2*	31.4 ± 9.2	5.2 ± 1.5	11.7 ± 1.6^*
Fraxinellone	Day 1	0.5 ± 0.4	4.1 ± 3.9	2.7 ± 2.0	-	-	0.6 ± 0.2
Fraxinellone	Day 7	-	-	-	-	-	-

^(*)

indicates the significant difference from Day 1 with Day 7 values, p < 0.05.