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. 2023 Oct 18;24(20):15330. doi: 10.3390/ijms242015330

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Schematic figure of the core polyamine metabolic pathway in eukaryotes. Met: methionine. MAT: S-adenosylmethionine synthase. SAM: S-adenosylmethionine. SAMDC: S-adenosylmethionine decarboxylase. dcSAM: decarboxylated S-adenosylmethionine. SPDS: spermidine synthase. SPMS: spermine synthase. SMO: spermine oxidase. OAZ: ornithine decarboxylase antizyme. ODC: ornithine decarboxylase. APAO: acetylpolyamine oxidase. AcSpd: acetylspermidine. SSAT: spermidine/spermine N1-acetyltransferase. AcSpm: acetylspermine.