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. 2023 Oct 18;24(20):15330. doi: 10.3390/ijms242015330

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Polyamine metabolism regulates the development of ovarian cancer. (Left) Inhibition of ODC, a key target of anabolic enzymes in polyamine metabolism, can hinder the development of ovarian cancer. (Middle) In normal cells, spermidine may regulate the translation of some autophagy-related genes by mediating hyp-eIF5A, thereby inhibiting the development of ovarian cancer. Spermidine may promote the development of ovarian cancer by regulating oncogene translation through hyp-eIF5A. (Right) Anticancer drugs inhibit the development of ovarian cancer by targeting the catabolic enzymes of polyamine metabolism, such as SSAT and SMO.