Table 3.
Changes in conventional echocardiographic parameters during treatment and at follow-up for the PhT and PBT Groups a.
| Transthoracic Echocardiography | ||||
|---|---|---|---|---|
| Parameter | Baseline | Midpoint | End Point | 3-Month Follow-Up |
| LVEF, % | ||||
| PhT | 61 ± 4 | 60 ± 4 | 61 ± 4 | 62 ± 3 |
| PBT | 61 ± 4 | 61 ± 4 | 61 ± 4 | 61 ± 4 |
| Septal S′, m/s | ||||
| PhT | 0.076 ± 0.014 | 0.072 ± 0.015 | 0.072 ± 0.013 | 0.068 ± 0.011 b |
| PBT | 0.070 ± 0.012 | 0.071 ± 0.017 | 0.072 ± 0.012 | 0.070 ± 0.015 |
| Lateral S′, m/s | ||||
| PhT | 0.077 ± 0.018 | 0.074 ± 0.021 | 0.080 ± 0.023 | 0.069 ± 0.016 b |
| PBT | 0.078 ± 0.017 | 0.079 ± 0.020 | 0.080 ± 0.022 | 0.085 ± 0.030 |
| LAVI, mL/m2 | ||||
| PhT | 23.2 ± 5.5 | 22.0 ± 6.1 | 22.5 ± 6.3 | 24.2 ± 6.9 |
| PBT | 24.0 ± 7.9 | 25.9 ± 7.8 | 25.1 ± 9.0 | 26.6 ± 7.2 |
| E/A | ||||
| PhT | 1.09 ± 0.46 | 1.10 ± 0.41 | 1.06 ± 0.52 | 1.10 ± 0.43 |
| PBT | 1.07 ± 0.35 | 1.10 ± 0.37 | 1.08 ± 0.38 | 1.08 ± 0.35 |
| E/e′ | ||||
| PhT | 8.40 ± 2.95 | 8.65 ± 2.25 | 8.40 ± 2.22 | 8.56 ± 2.43 |
| PBT | 8.29 ± 2.99 | 7.73 ± 2.99 | 7.76 ± 2.24 | 7.85 ± 2.41 |
| Septal e′, m/s | ||||
| PhT | 0.077 ± 0.021 | 0.069 ± 0.019 b | 0.074 ± 0.020 | 0.079 ± 0.024 |
| PBT | 0.082 ± 0.023 | 0.087 ± 0.025 | 0.088 ± 0.028 | 0.090 ± 0.032 |
| Lateral e′, m/s | ||||
| PhT | 0.089 ± 0.024 | 0.092 ± 0.031 | 0.094 ± 0.028 | 0.097 ± 0.030 |
| PBT | 0.095 ± 0.031 | 0.102 ± 0.032 | 0.100 ± 0.033 | 0.099 ± 0.034 |
Abbreviations: E/A, ratio of early (E) to late (A) mitral inflow velocity; E/e′, ratio between early mitral inflow velocity and mitral annular early diastolic tissue velocity; e′, early diastolic tissue Doppler velocity; LAVI, left atrial volume indexed to body surface area; LVEF, left ventricular ejection fraction; PBT, proton beam therapy; PhT, photon therapy; S′ TDI, systolic tissue Doppler velocity. a All data expressed as mean ± SD. b p < 0.05 from the baseline value.