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. 2023 Oct 21;24(20):15422. doi: 10.3390/ijms242015422

Figure 2.

Figure 2

Hypoxia–associated changes in gene expression in control– and patient–derived EC. (A) Relative expression change in targets associated with hypoxia in pooled EC of control and P1 cells (yellow: downregulation, blue: upregulation). (B) Target validation revealed no difference in relative gene expression between control, P1, and P2 (HIF1a: n = 2 per clone, 2 clones per cell line, HIF2, ADM, VEGFA: n = 3 per clone, 2 clones per cell line). Abbreviations: ADM: adrenomedullin, ANGPTL4: angiopoietin-like 4, DDIT4: DNA damage-inducible transcript 4, DDIT4L: DNA damage-inducible transcript 4-like, HIF: hypoxia-inducible factor, IGFBP1: insulin-like growth factor-binding protein 1, P1,2: Fabry patients, VEGFA: vascular endothelial growth factor A. Statistics: Kruskal–Wallis test in Figure 2B.