Table 4.

GRADE (Grading of Recommendations, Assessment, Development, and Evaluations) criteria for assessing the quality of evidence.

Outcome	Number of Studies	Number of Participants	Risk of Bias	Imprecision	Inconsistency	Indirectness	Publication Bias	Relative Effect (95% Confidence Interval)	Confidence in Effect Estimate (Grade)
Pain	4	229	Serious	Serious	Moderate	Not serious	Serious	−0.31 (−0.53, −0.08)	Very low
WOMAC	4	276	Serious	Serious	Serious	Not serious	Serious	−0.80 (−1.08, −0.53)	Very low
Adverse effect	5	329	Serious	Serious	Not serious	Not serious	Serious	1.37 (0.79, 2.37)	Very low