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Bone remodeling. Osteoblasts express soluble and membrane-bound RANKL which binds to RANK in the membrane of osteoclast precursors. RANK signaling activates the differentiation towards osteoclasts. RANK signaling in osteoclasts promotes their bone resorptive activity and survival. Osteoblasts infiltrate into the cavities and synthesize the bone matrix. OPG is a decoy receptor produced by osteoblasts that binds RANKL, inhibiting the RANK signaling and regulating bone remodeling.
