Table 1.
Characteristics of the patients with systemic sclerosis.
| Characteristics of Patients with Systemic Sclerosis | All Patients (N 50) |
Patients with Interstitial Lung Disease (N 30) | Patients without Interstitial Lung Disease (N 20) |
p Value |
|---|---|---|---|---|
| Age | 63 (54–70) | 64 (54–72) | 60 (46–65) | 0.17 * |
| Gender: Male | 5 (10) | 4 (13) | 1 (5) | 0.64 † |
| Female | 45 (90) | 26 (87) | 19 (95) | |
| Duration of disease, years | 9 (5–17) | 13 (7–22) | 6 (5–10) | 0.01 * |
| BMI | 25.5 (23.2–29.1) | 24.3 (23.1–26.4) | 28.27 (23.2–31.0) | 0.10 * |
| Weight (kg) | 68.5 (60–82.5) | 65.5 (56.8–72.3) | 78 (65–94.25) | 0.05 * |
| Height (cm) | 165 (158–170) | 162 (158–170.3) | 166 (165–170) | 0.09 * |
| Anti-Scl-70 antibodies | 18 (36) | 14 (47) | 4 (20) | 0.07 † |
| Anticentromere antibodies | 16 (32) | 6 (20) | 10 (50) | 0.03 † |
| mRSS | 6.5 (2–13) | 9.5 (1.75–13) | 4 (2–13) | 0.38 * |
| Gastroesophageal symptoms | 41 (82) | 28 (93) | 13 (65) | 0.02 * |
| Pulmonary hypertension | 10 (20) | 9 (30) | 1 (5) | 0.04 † |
| FEV1/FVC | 0.79 (0.8–0.8) | 0.79 (0.8–0.8) | 0.76 (0.7–0.8) | 0.12 * |
| FEV1 (%) | 91 (81.8–101.8) | 87 (77.3–99.5) | 97.5 (87–104.8) | 0.03 * |
| FVC (%) | 98.5 (84–109.3) | 91 (78–105.8) | 102 (96.3–109.8) | 0.03 * |
| MMEF (%) | 70 (48–92) | 64 (45–83) | 84 (68.3–105.8) | 0.02 * |
| DLCO (%) | 69.5 (58.5–85.3) | 64.5 (47.5–70.5) | 81.5 (73–98.8) | <0.001 * |
| KCO (%) | 80.5 (67.3–90.8) | 76 (63–82) | 87.5 (72.5–97.3) | 0.01 * |
| VA (%) | 90 (79–101) | 84 (72.5–95) | 97.5 (90–105) | 0.002 * |
| Ground-glass opacities | 28 (56) | 26 (87) | 2 (10) | <0.001 † |
| Irregular pleura | 25 (50) | 22 (73) | 3 (15) | <0.001 † |
| Septal/subpleural lines | 37 (74) | 29 (97) | 8 (40) | <0.001 † |
| Honeycombing | 5 (10) | 5 (17) | 0 | 0.08 † |
| Subpleural cysts | 7 (14) | 7 (23) | 0 | 0.03 † |
| Esophageal diameter at location 1 (mm) | 8 (6–14) | 12 (7.5–16) | 7 (6–8) | <0.001 * |
| Esophageal diameter at location 2 (mm) | 12 (7.5–18.5) | 17 (9.5–22.5) | 8 (7–10.75) | <0.001 * |
| Esophageal diameter at location 3 (mm) | 16 (10.5–21) | 20 (13–25.5) | 11 (9–16) | 0.001 * |
* Mann–Whitney U test; † Fisher’s Exact Test; BMI—body mass index; mRSS—modified Rodnan skin score; FEV1—forced expiratory volume in the first second; FVC—forced vital capacity; MMEF—mid-maximum expiratory flow; DLCO—diffusing capacity for carbon monoxide; KCO—carbon monoxide transfer coefficient; VA—alveolar volume.