Figure 10.

(A) Sequence alignment of TDP-43 glycine-rich low complexity domain (LCD) 274–414 a.a. with β-strand regions observed in in vitro-aggregated LCD and in ex vivo extracted TDP-43 assemblies. The location of β-strands for in vitro-aggregated LCD is shown as represented on Figure 1d from [89], for ex vivo extracted TDP-43 assemblies (ALS with FTLD)—as in Extended Figure 4a from [90]. (B) Schematic representation of in vitro-derived and ex vivo ALS-with-FTLD-specific folds of TDP-43 LCD.