Table 4.

Comparison of results in a systematic review (Source: own elaboration).

Author	Treatment Period	Improvements in the Ozone Group
Hassan	3 months	Increase in the % cure in those treated with ozone.
Wainstein	12 weeks	Higher proportion in total closure of the wound (81% vs. 44%).
Zhang	20 days	Significant wound reduction (p < 0.001). Global effective rate of 92%.
Solovąstru	30 days	Wound reduction (p < 0.05). Complete closure in 25% of patients.
Teuvov	According to each patient	Reduction in days in bed and microbial bodies. Increases regeneration speed.
Hassanien	20 days	96% healing rate. Increase in VEGF and reduction in antiETAR (p < 0.001).
Izadi	180 days or complete closure	100% total closure, decreased healing time (p = 0.012), lower % of amputation (p < 0.05).
Kadir	21 days	Reduction in the number of bacterial colonies (p = 0.037).
Kaymaz	4 weeks	Healing effectiveness rate of 92%. Decrease in size (p = 0.027) and pain (p < 0.01).
Menendez	3 months	90.5% were completely cured, 9.5 improved their condition.
Lu	4 weeks	There were no differences between the two groups.
Illek	3 months	Disappearance of symptoms after the end of treatment. They appear 10 months later in the ozone group and three months later in the control group.
Zeng	3 days	Bacterial skin restoration (p = 0.023).
Campanati	12 weeks	Patients treated with ozone presented less intense hyperpigmentation after healing (p = 0.03).
Martusevich	15 days.	No significant differences were observed between both groups.
Curro	7 days	Increase in growth factors (p < 0.001).
Aghaei	2 months	Decrease in size, there were no significant differences. Mild post-inflammatory hyperpigmentation in the ozone group after healing.
Ibrahim	Maximum 10 sessions or until full authorization.	Response to treatment of 90.9%. Recurrence rate after 6 months of treatment (5% vs. 15%).