. Author manuscript; available in PMC: 2024 Aug 1.

Published in final edited form as: J Am Geriatr Soc. 2023 Jun 30;71(8):2393–2405. doi: 10.1111/jgs.18483

Table 2:

Common and Study-specific Measurements in SPRING

Resilience Measurement Categories	Common Measures across studies	Bone Marrow Transplant (REBOUND) study only	Dialysis Initiation (ReDI) study only	Knee Replacement (RESTORE) study only
Baseline Contributors	Age, demographics, SES, psychosocial measures, health behaviors, disease meas-ures, medicat-ions, biological measures: immune cell phenotypes, 24-hour catechol-amines, metabol-omic markers	DNA methylation / methylation clock, malignancy type, cytogenetic risk group	Pre-dialysis course, cause of end-stage renal disease, type of dialysis access	Senescent cell markers
Stressor characteristics	n/a	Dose and type of chemotherapy, total body dose of radiation, conditioning regimen	Interdialytic weight gain, volume removed, dialysis treatment time, dialysate temperature, electrolyte composition, treatment adherence	Anesthesia type & dose, time in surgery, blood loss, fluids administered, transfusion and/or pressor use, use of cement, use of tourniquet, need for intubation, intraoperative temperature, postoperative opioid use
Static Surrogate Measures ^*	Phenotypic frailty, SF-36, nutrition (albumin, total cholesterol, vitamin D), Karnofsky performance measure ¹⁴	ECOG¹⁵ performance measure, HCT-specific comorbidity index	KDQOL, NYHA self-reported symptoms	Knee Injury and Osteoarthritis Outcome Score (KOOS)
Dynamic Stimulation Indicator Measures	ACTH stimulat-ion, 24-hour salivary cortisol profile, dynamic ex-vivo response of immune cells, Orthostatic Blood Pressure, Holter monitoring*; Observed Fatigability treadmill test	Oral glucose tolerance test	n/a	Oral glucose tolerance test
Resilience Phenotype Measures ^*	Physical function (SPPB, mobility function), accelerometry, cognitive function (MOCA, DSST, NIH Cognition Toolbox), ADLs/IADLs, Pittsburgh fatigability scale, sleep, physiologic markers including inflammatory markers, hormones, clotting factors
Clinical Outcomes	Hospitalization/re-hospitalization, falls, morbidity, mortality	Graft versus host disease, relapse, infection, rehab or skilled nursing facility, new malignancies, post-transplant therapies	Kidney transplantation, transfer to home dialysis modality, uremic symptoms (pruritus, fatigue, anorexia, pain, restless legs), health-related quality of life	NSQIP post-op 30-day complic-ations, LOS until discharge, delirium, dis-charge home, rehab, ambulate unaided 60 days later, independ-ent living; CCI change, patient satisfaction with surgery, post-operative pain

measured pre and post clinical stressor

Abbreviations: SES=Socioeconomic status; ACTH= Adrenocorticotropic hormone; SPPB=short physical performance battery; MOCA=Montreal cognitive assessment; DSST=Digital symbol substitution test; NIH=National Institute of Health; ADL=Activities of daily living; IADL=instrumental activities of daily living; NSQIP= National Surgical Quality Improvement Program; LOS=Length of stay; KDQOL=Kidney Disease Quality of Life; NYHA=New York Heart Association; HCT=Hematopoietic cell transplantation; DNA=Deoxyribonucleic acid; ECOG=Eastern Cooperative Oncology Group; CCI=Charlson Comorbidity Index. The NIH Cognitive Toolbox tests included in SPRING are Flanker Inhibitory Control and Attention Test; Auditory Verbal Learning Test; and Pattern Comparison Test.