Table 3:

Validation of Top up- and down-regulated genes and key regulatory genes in sepsis

Top Down-Regulated Genes	Controls n=25	Sepsis n=18	Log 2 fold change	P-Value (BH)
IL-1α	0.03	0.04	0.49	0.26
LGALS2	1.90	0.40	−2.26	0.0003
CCL20	0.00	0.01	1.06	0.17
PLD4	1.66	0.13	−3.73	0.0000003
TIGD3	0.76	0.11	−2.75	0.00000002
PPP2R2B	0.53	0.09	−2.51	0.0009
CCR3	4.87	1.15	−2.08	0.0000008
FXYD7	0.09	0.01	−2.85	0.000002
ALOX15	1.50	0.05	−4.79	0.004
ADAMTS10	0.63	0.10	−2.68	0.00000006
FCER1A	3.78	0.33	−3.51	0.00000000
CYP2S1	0.63	0.19	−1.76	0.0002
Top Up-Regulated Genes
GPR84	0.28	6.11	4.43	0.0000004
MMP8	0.87	48.96	5.81	0.0007
OLFM4	0.36	5.52	3.96	0.006
LCN2	0.97	12.23	3.65	0.0009
ANKRD22	0.55	8.31	3.91	0.0007
TNFAIP6	3.78	0.33	−3.51	0.00000001
G0S2	0.77	5.15	2.74	0.0000022
CCL3	0.50	0.29	−0.80	0.02
Regulatory Genes
OSM	1.37	7.05	2.36	0.000002
CEBPB	22.49	60.58	1.43	0.000002
S100A8	167.60	1524.61	3.19	0.00002
NFKB1	4.35	5.35	0.30	0.08
SOCS1	2.50	3.88	0.63	0.28
IL-1β	8.32	17.17	1.05	0.0008
TLR4	23.11	57.08	1.30	0.00004
EIF2AK2	1.88	2.98	0.67	0.15
TICAM1	1.93	1.89		0.87
CD40LG	3.73	0.71	−2.38	0.0000004
TLR2	30.12	73.27	1.28	0.00002
CAMP	3.25	6.90	1.09	0.05
IL-8	0.62	1.10	0.82	0.14
MAPK14	25.82	102.19	1.98	0.00000009
HGF	0.87	6.41	2.88	0.0009
TGM2	0.49	0.61	0.31	0.27
IRF7	6.51	11.85	0.86	0.026
HIF1A	4.99	11.19	1.16	0.00002
C3	0.13	0.22	0.79	0.11
NFKBIA	8.37	17.74	1.08	0.000002
TLR5	2.40	12.46	2.37	0.0000001
NFE2L2	9.78	16.08	0.72	0.0007
TGFA	1.94	4.30	1.15	0.0009
CYP1B1	5.89	24.79	2.07	0.001
MAP3K8	1.95	3.11	0.67	0.006