Table 3.
Toxicity profiles of MMZ compounds estimated using Protox-II (http://tox.charite.de/protox_II, accessed on 26 February 2023).
| Compound /Property | Hepatotoxicity | Immunotoxicity | Mutagenicity | ATAD5 | HSE | MMP | nrf2/ARE | TP53 |
|---|---|---|---|---|---|---|---|---|
| MMZ-33 | Inactive (p = 0.55) |
Inactive (p = 0.98) |
Inactive (p = 0.56) |
Inactive (p = 0.85) |
Inactive (p = 0.92) |
Active (p = 0.59) |
Inactive (p = 0.92) |
Inactive (p = 0.8) |
| MMZ-39 | Active (p = 0.5) |
Inactive (p = 0.93) |
Inactive (p = 0.64) |
Inactive (p = 0.88) |
Inactive (p = 0.86) |
Active (p = 0.6) |
Inactive (p = 0.86) |
Inactive (p = 0.72) |
| MMZ-45 | Inactive (p = 0.64) |
Inactive (p = 0.99) |
Inactive (p = 0.54) |
Inactive (p = 0.88) |
Inactive (p = 0.93) |
Inactive (p = 0.61) |
Inactive (p = 0.93) |
Inactive (p = 0.85) |
| MMZ-140 | Inactive (p = 0.82) |
Inactive (p = 0.86) |
Inactive (p = 0.51) |
Inactive (p = 0.95) |
Inactive (p = 0.95) |
Inactive (p = 0.69) |
Inactive (p = 0.95) |
Inactive (p = 0.92) |
| MMZ-147 | Inactive (p = 0.65) |
Inactive (p = 0.99) |
Inactive (p = 0.5) |
Inactive (p = 0.86) |
Inactive (p = 0.94) |
Inactive (p = 0.56) |
Inactive (p = 0.94) |
Inactive (p = 0.74) |
| MMZ-167 | Inactive (p = 0.62) |
Inactive (p = 0.86) |
Inactive (p = 0.6) |
Inactive (p = 0.86) |
Inactive (p = 0.63) |
Inactive (p = 0.61) |
Inactive (p = 0.93) |
Inactive (p = 0.83) |
p—probability.