Figure 6.

Effect of GTN on the pathogenesis of S. marcescens. Photomicrographs of H&E-stained sections were captured from (A) liver and (B) kidney of uninfected mice groups displaying typical tissue structure and normal cellular characteristics. Photomicrograph of liver sections isolated from infected mice displaying congestion of blood vessels (arrow) with diffuse hydropic degeneration of hepatocytes (arrow) (C). Additionally, diffuse spreading of microorganisms in the hepatic parenchyma (arrows) with diffuse infiltration of von Kupffer cells (arrow) (D). Photomicrograph of kidney sections isolated from infected mice displaying (E) perivascular colonization of the microorganism beside inflammatory cell infiltration (arrow) in addition to cloudy swelling of some renal tubules (arrowhead) and (F) perivascular colonization of microorganism beside inflammatory cell infiltration (arrow) with severe congestion (arrowhead) in addition to cloudy swelling of some renal tubules (tailed arrow) and focal renal epithelium pyknosis (curved arrow). In contrast, the photomicrograph of sections captured from the GTN-treated mice group showed mild congestion of hepatic blood vessels (arrow) with apparently normal hepatic parenchyma (G), and mild degenerative changes represented in the cloudy swelling of some renal tubules (arrow) (H).