Table 1.

Design matrix for the selective SFE design of the experiment (BBD) using CNPE with responses for non-polar compounds of interest (faradiol esters) and narcissin (UV response 354 nm UC-DAD).

Experiment N°	Coded Levels			Results (after 30 min of Extraction)
	X 1	X 2	X 3	Faradiol Myristate (mAU × min)	Faradiol Palmitate (mAU × min)	Both Faradiol Esters (Y) (mAU × min)	Narcissin (µv × s)	Dried Extract Yield (mg/g)
	Temperature (°C)	Pressure (MPa)	EtOH (%)
1	40 (−1)	10 (−1)	10 (0)	3.11 × 108	2.54 × 108	5.64 × 108	0.00	58.9
2	80 (+1)	10 (−1)	10 (0)	5.46 × 108	4.65 × 108	1.01 × 109	4.08 × 105	88.5
3	40 (−1)	20 (+1)	10 (0)	2.78 × 108	2.31 × 108	5.08 × 108	0.00	62.5
4	80 (+1)	20 (+1)	10 (0)	5.50 × 108	4.77 × 108	1.03 × 109	0.00	76.1
5	40 (−1)	15 (0)	5 (−1)	3.94 × 108	3.27 × 108	7.20 × 108	0.00	56.5
6	80 (+1)	15 (0)	5 (−1)	1.99 × 108	9.61 × 107	2.95 × 108	0.00	41.5
7	40 (−1)	15 (0)	15 (+1)	5.39 × 108	4.66 × 108	1.00 × 109	3.23 × 105	69.7
8	80 (+1)	15 (0)	15 (+1)	1.39 × 109	1.26 × 109	2.66 × 109	0.00	92.3
9	60 (0)	10 (−1)	5 (−1)	1.30 × 108	5.79 × 107	1.88 × 108	0.00	35.2
10	60 (0)	20 (+1)	5 (−1)	3.65 × 108	3.13 × 108	6.79 × 108	0.00	55.5
11	60 (0)	10 (−1)	15 (+1)	6.81 × 108	5.73 × 108	1.25 × 109	3.04 × 105	85.4
12	60 (0)	20 (+1)	15 (+1)	6.50 × 108	5.53 × 108	1.20 × 109	3.15 × 105	102.6
13	60 (0)	15 (0)	10 (0)	5.77 × 108	4.93 × 108	1.07 × 109	0.00	73.4
14	60 (0)	15 (0)	10 (0)	5.68 × 108	4.68 × 108	1.04 × 109	0.00	70.7
15	60 (0)	15 (0)	10 (0)	5.82 × 108	4.82 × 108	1.06 × 109	0.00	68.1
16	60 (0)	15 (0)	10 (0)	6.59 × 108	5.49 × 108	1.21 × 109	0.00	71.5
17	60 (0)	15 (0)	10 (0)	4.59 × 108	3.86 × 108	8.45 × 108	0.00	65.5