Table 2.
MIC and MBIC values (µM) of zinc, nickel(II) and copper(II) complexes against M. bovis BCG, M. marinum and M. tuberculosis.
| Compound | M. bovis BCG | M. marinum | M. tuberculosis H37Ra | |||
|---|---|---|---|---|---|---|
| MIC | MBIC | MIC | MBIC | MIC | MBIC | |
| µM | µM | µM | µM | µM | µM | |
| HA2Zn2 | >500 | >500 | >500 | 500 | >500 | 250 |
| HA6Zn2 | >500 | 200 | >500 | 500 | 125 | 125 |
| HA8Zn2 | >500 | 100–200 | >500 | 500 | 250 | 250 |
| HA10Zn2 | 250 | 100 | 250 | 250–500 | 250 | 250 |
| HA12Zn2 | >500 | 100 | >500 | 250 | 250 | 125 |
| HA17Zn2 | >500 | >500 | >500 | 500 | >500 | 250 |
| HA2Ni2 | >500 | 300–500 | >500 | >500 | >500 | 62.5–125 |
| HA6Ni2 | >500 | 200 | >500 | 500 | >500 | 31.25 |
| HA8Ni2 | >500 | 100 | >500 | 62.5 | >500 | 31.25 |
| HA10Ni2 | >200 | 20 | >200 | 500 | 500 | 125 |
| HA12Ni2 | >500 | 100 | >500 | 125 | >500 | 250–500 |
| HA17Ni2 | >500 | >500 | >500 | 250 | >500 | 250 |
| HA2Cu2 | 250–500 | 300 | >500 | ≥250 | ≥500 | 250 |
| HA6Cu2 | ≥500 | 100 | >500 | 500 | >500 | 500 |
| HA8Cu2 | >200 | 100–200 | >200 | 250 | >500 | 250 |
| HA10Cu2 | >200 | 20 | >200 | 250 | 250 | 250 |
| HA12Cu2 | >500 | 100 | >500 | 125 | >500 | 250 |
| HA17Cu2 | >500 | ≥500 | >500 | ≥500 | >500 | 250 |
HAZn2 = zinc complexes, HAnNi2 = nickel(II) complexes, HAnCu2 = copper(II) complexes with n = 2, 6, 8, 10, 12 and 17 (carbon chains).