Table 1.
Clinical trials using the KD in breast cancer patients registered at https://clinicaltrials.gov (accessed on 20 July 2023).
| ClinicalsTrials Identifier |
Status | Objective of the Clinical Trial | Intervention | Disease |
|---|---|---|---|---|
| NCT05234502 | O | Impacts of KD on Overweight and Obese Women Diagnosed with Breast Cancer | Alternative 1: Comprehensive and Well-Balanced Diet Regimen (Carbohydrates: 45–60%, Protein: 10–20%, Fat: 20–35%) Alternative 2: Ketogenic Diet Regimen (Carbohydrates: 6%, Protein: 19%, Fat: 75%) |
Breast Cancer Female |
| NCT03962647 | O | Two-Week Ketogenic Diet Coupled with Letrozole for the Regulation of PI3K Signaling in ER+ Breast Cancer | Supplemental Diet: Two-Week Ketogenic Diet Regimen Pharmaceutical Treatment: Letrozole |
Estrogen Receptor-positive Breast Cancer |
| NCT03535701 | C | Exploring the Role of Ketogenic Diet and Chemotherapy in Modulating Recurrence in Stage IV Breast Cancer Patients | Nutritional Addendum: Dietary Intervention Strategy Alternate: Analysis of Lab-Based Biomarkers Pharmaceutical: Administration of Paclitaxel |
Stage IV Breast Cancer AJCC v6 and v7 |
| NCT05090358 | O | Mitigating Hyperglycemia in Patients Undergoing Treatment for Metastatic Breast Cancer | Nutritional Supplement: Implementation of the KD Nutritional Supplement: Adoption of a Low-Carbohydrate Diet Pharmaceutical: Usage of Alpelisib |
Breast Cancer Breast Cancer Stage IV Metastatic Breast Cancer |
| NCT04469296 | O | Adjusting Nutritional Intake in Luminal Early Stage Breast Cancer Patients Candidate for Primary Surgery | Nutritional Intervention 1: Iso-Caloric KD Regimen Nutritional Intervention 2: Protein-Limited Dietary Approach |
Breast Cancer Surgery |
| NCT02092753 | C | Exploring Ketogenic or LOGI Dietary Approaches in Breast Cancer Recovery Intervention (KOLIBRI Study) | Alternate Approach: Standard Dietary Plan (SD) Experimental Approach 1: Ketogenic Dietary Regimen (KD) Experimental Approach 2: Low Glycemic and Insulinemic Diet (LOGI) |
Quality of Life |
| NCT02744079 | C | Comparative Study of Healthful Dietary Patterns on Biomarkers of Breast Cancer | Behavioral Modification 1: Adoption of a Low-Carbohydrate Diet Behavioral Modification 2: Implementation of a Low-Fat Diet |
Breast Neoplasms |
Abbreviations: C, closed; O, ongoing. A more detailed description of the studies reported in Table 1 is provided below to better elucidate the main results obtained by using the KD in patients with BC.