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. 2023 Sep 22;11(10):2371. doi: 10.3390/microorganisms11102371

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Significantly changed pathway in metabolite set enrichment analysis with PyrR editing. (A) Metabolite set enrichment analysis showing metabolic pathways enriched in the L. casei ΔPyrR compared to the L. casei. (B) The expression of differential metabolites in the pyrimidine and purine pathway (shown via a heatmap). (C) The expression of differential metabolites in the biosynthesis of secondary metabolites pathway (shown via a heatmap). (D) Correlation network analysis based on the integrated metabolomic and differential abundance score.