. 2023 Oct 19;15(10):2494. doi: 10.3390/pharmaceutics15102494

Table 3.

Cytotoxicity and antiviral effects against ZIKV upon treatment of Vero cells with naringenin, 7-O-methyl naringenin and 6-MMPr.

	^d# CC₂₀ (μM/mL)	^a# CC₅₀ (μM/mL)	^b# IC₅₀ (μM/mL)	^c# SI
Naringenin	86.43	241.6	58.89	4.1
7-O-methyl naringenin	105.2	240.4	12.80	18.7
6-MMPr	60.5	291	24.5	11.9

^a CC₅₀ (50% cytotoxic concentration) compound concentration to reduce 50% of viability. ^b IC₅₀ (50% inhibitory concentration) compound concentration to reduce 50% viral titer when compared with untreated cells. ^c Selective index (SI) based on the ratio calculation of CC₅₀ and IC₅₀ values. ^d CC₂₀ (20% cytotoxic concentration), the non-toxic concentration used in the antiviral assays. ^# Results are defined by the mean values of three independent experiments.