Figure 4.

AFG biomimetic hydrogel for neural tissue repair. (A) AFG was implanted in hollow chitosan tubes under the condition of NTFs, creating a beneficial environment. (B) AFG helped SC cells of nerve stumps to migrate and align in vivo, forming cell cables. (C) Guided by the cell cords, axons began to sprout and regenerate. (D) Under the combined action of AFG, SC cells, NTFs, and regenerating axons, the myelination were formed, which facilitated the restoration of neurons. NTFs: neurotrophic factors; AFG: aligned fibrin nanofiber hydrogel (AFG); SC: Schwann cell.