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. 2023 Oct 18;15(20):4427. doi: 10.3390/nu15204427

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Germ-depletion and butyrate supplementation treatment attenuate necrosis of pancreatic tissue and systemic inflammation in L-arginine-induced acute pancreatitis. (A) Scheme of germ-depletion and butyric acid supplement groups. (B) Serum amylase, lipase, and LBP levels. (C) H&E-stained sections of the pancreas and IF sections of the intestinal barrier with expression levels of Zo-1 (green) and occludin (green) measured with qPCR. (D) SOD in pancreatic tissue. (E) MDA in pancreatic tissue. (F) Cytokines in serum. (G) Chemokines in serum. All data were shown with mean ± SD, * p < 0.05, ** p < 0.01, *** p < 0.001, ns = not significant.