Table A1.
Data sources of genetic association for the exposures and the outcomes.
| Trait | Unit | Cohort(s) or Consortium | Simple Size or Cases/Sample Size | First Author, Year |
|---|---|---|---|---|
| Exposures | PIVUS, SHIP-TREND, SKIPOGH, TwinGene, TwinsUK, ULSAM | |||
| Plasma caffeine level | SD | 9876 | Cornelis, 2016 [17] | |
| Caffeine intake | SD | ARIC, PLCO, NHS, HPFS, WGHS | 47,341 | Cornelis, 2011 [16] |
| Outcome | ||||
| eGFRcyst | log(mL/min/1.73 m2) | CKDGen + UK Biobank | 460,826 | Stanzick, 2021 [19] |
| eGFRcrea | log(mL/min/1.73 m2) | CKDGen + UK Biobank | 1,004,040 | Stanzick, 2021 [19] |
| Urinary sodium | SD | UK Biobank | 326,831 | Hemani, 2018 [23] |
| BUN | log/mg/dL) | CKDGen | 480,698 | Wuttke, 2019 [20] |
| UACR | log(mg/mmol) | CKDGen | 192,868 | Teumer, 2019 [21] |
| CKD | log(OR) | CKDGen | 41,395/439,303 | Wuttke, 2019 [20] |
Abbrevations: ARIC: Atherosclerosis Risk in Communities; BUN: Blood Urea Nitrogen; CKD: Chronic Kidney Disease; CKDGen: Chronic Kidney Disease Genetics Consortium; eGFRcyst: Glomerular Filtration Rate estimated using cystatin C; eGFRcrea: Glomerular Filtration Rate estimated using creatinine; HPFS: the Health Professionals Follow-Up Study; NHS (the Nurses’ Health Study); PIVUS: the Prospective Study of the Vasculature in Uppsala Seniors (PIVUS); PLCO: the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial; SHIP-TREND: the Study of Health in Pomerania TREND; SKIPOGH: the Swiss Kidney Project on Genes in Hypertension; UACR: urine albumin-creatinine ratio; ULSAM: Uppsala Longitudinal Study of Adult Men (ULSAM); WGHS: the Women’s Genome Health Study.