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. 2023 Oct 17;15(10):2483. doi: 10.3390/pharmaceutics15102483

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Promotion of apoptosis in tumor cells by MSNs-loaded siRNAs. (A) Scheme of the preparation process of Vorinostat and cFLIP siRNA-coloaded mesoporous silica nanoparticles with pH-ultrasensitive valves (Vor/siR@MSN-PB-PEG) for suppression of cFLIP in cancer cells, Vor/siR@MSN-PB-PEG-inhibited cFLIP expression, and induced apoptosis caspase pathways in cancer cells; (B) EGFR-targeted (cetuximab) mesoporous silica nanoparticle (NP) platform for PLK1 siRNA (siPLK1) delivery or C-siPLK1-NP and proapoptotic effects of C-siPLK1-NP treatment on NSCLC (A549, H460) cell lines. * p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001, ns = not statistically significant.