Table 1.
General characteristics and biological properties for the cationic peptides GA-Hecate, PSSct1905, and PSSct1910. MW: molecular weight. MNTC: maximum nontoxic concentration. CC50: 50% cytotoxic concentration. EC50: 50% effective concentration. SI: selectivity index.
| BHK-21 Cells | Huh-7 Cells | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Peptide | Length | MW | Net Charge | MNTC (µM) | CC50 (µM) |
EC50 (µM) |
SI | CC50 (µM) |
EC50 (µM) |
SI |
| GA-Hecate | 23 | 2688.43 | +9 | 12.5 | 23.3 | 5.7 | 4.1 | 221 | 4.5 | 49.1 |
| PSSct1905 | 15 | 1808.25 | +4 | 12.5 | 56.5 | 8.4 | 6.7 | 205 | 7.1 | 28.9 |
| PSSct1910 | 23 | 2684.17 | +9 | 1.6 | 5.4 | 1.1 | 4.9 | 7.7 | 0.2 | 38.5 |