Table 3.

Lists of clinical trials of silver and gold NPs.

NPs Type	Study Title	Material	Targeted Condition	Clinical trials.gov Identifier
AgNPs	Topical Silver Nanoparticles for Microbial Activity	Topical cream containing silver NPs	Fungal foot infection Bacterial infection	NCT03752424
	Topical Application of Silver Nanoparticles and Oral Pathogens in Ill Patients	Innocuous gel compound with 12 ppm of AgNPs	Dental diseases	NCT02761525
	Silver Nanoparticles in Multidrug Resistant Bacteria	AgNPs	Multidrug resistant bacteria	NCT04431440
	Nanosilver Fluoride to Prevent Dental Biofilms Growth	Nanosilver fluoride	Dental caries	NCT01950546
	Remineralization of Dentine Caries Using Two Remineralizing Agents Which Are Nanosilver Fluoride and Casein phosphopeptides amorphous Calcium Phosphate	Nanosilver fluoride vs. sodium fluoride with casein phosphopeptides amorphous calcium phosphate on carious lesion	Dental caries	NCT04930458
	Radiographic Assessment of Glass Ionomer Restorations with and Without Prior Application of Nano Silver Fluoride in Occlusal Carious Molars Treated with Partial Caries Removal Technique	Nano silver fluoride solution	Partial dentin caries removal	NCT03193606
	Clinical Evaluation of Silver Nanoparticles in Comparison to Silver Diamine Fluoride in Management of Deep Carious Lesions	AgNPs vs. silver diamine fluoride	Caries, dental therapy	NCT05231330
	Addition of Silver Nanoparticles to an Orthodontic Primer in Preventing Enamel Demineralization Adjacent Brackets	AgNPs incorporated into the primer orthodontic Transbond XT	Tooth demineralization	NCT02400957
	Evaluation of Antimicrobial Efficacy and Adaptability of Bioceramic Sealer Containing Nanoparticles	Bioceramic sealers with classic mix vs. AgNPs vs. chitosan	Endodontic disease	NCT04481945
	Silver Nanoparticle Investigation for Treating Chronic Sinusitis	Topical colloidal silver	Chronic rhinosinusitis	NCT03243201
	The Antibacterial Effect of Nanosilver Fluoride on Primary Teeth	Topic solution of silver fluoride NPs	Microbial colonization for preventing dental caries in children	NCT05221749
	Colloidal Silver, Treatment of COVID-19	Inhalation colloidal silver solution	SARS (severe acute respiratory syndrome)	NCT04978025
	Evaluation of Silver Nanoparticles for the Prevention of COVID-19	AgNPs solution with 1 wt% concentration (0.6 mg/mL metallic silver) for mouthwash and nose rinse	Coronavirus disease (COVID-19)	NCT04894409
	SARS-CoV-2-Spike-Ferritin-Nanoparticle (SpFN) Vaccine with ALFQ Adjuvant for Prevention of COVID-19 in Healthy Adults	SpFN COVID-19 vaccine with Army Liposomal Formulation QS21 (ALFQ) adjuvant	SARS-CoV-2 infection	NCT04784767
	Fluor Varnish with Silver Nanoparticles for Dental Remineralization in Patients with Trisomy 21	Fluor dental varnish plus 25% 50 nm AgNPs vs. fluor dental varnish	Dental remineralization, Down syndrome	NCT01975545
	Comparison of Central Venous Catheters with Silver Nanoparticles Versus Conventional Catheters	Central venous catheter impregnated with AgNPs (AgTive®)	Central venous catheter related infections	NCT00337714
	Evaluation of Diabetic Foot Wound Healing Using Hydrogel/Nano Silver-based Dressing vs. Traditional Dressing	Hydrogel/nano silver-based dressing	Diabetic foot wound	NCT04834245
	Efficacy of Silver Nanoparticle Gel Versus a Common Antibacterial Hand Gel	Nano-silver gel exposed vs. alcohol-based hand gel	Antibacterial activity in normal patients’ skin	NCT00659204
	Post-operative Pain Reduction	Conventional calcium hydroxide paste vs. combined calcium hydroxide with AgNPs	Effects of the elements	NCT04338633
	A Phase I/II Double-blind Safety and Efficacy Evaluation of Nowarta110 in Patients with Plantar Warts	Nowarta 110, a colloidal silver fig extract for topical administration	Plantar warts	NCT02338336
	Research on the Key Technology of Burn Wound Treatment	Nano-silver ion gel and dressings for wounds	Burn wounds	NCT03279549
	Altrazeal Range of Motion Study Comparing with Typical Carboxymethyl	Hydrogel nanoparticle wound dressing	Burn wounds	NCT01062191
	Assessment of Postoperative Pain After Using Various Intracanal Medication in Patients with Necrotic Pulp	AgNPs in gel form vs. calcium hydroxide intracanal medication	Postoperative pain	NCT03692286
	Preadmission Skin Wipe Use for Surgical Site Infection Prophylaxis in Adult Orthopaedic Surgery Patients	Bath wipes impregnated with multiple ingredients, among which colloid silver	Surgical site infection	NCT03401749
	Thyme and Carvacroll Nanoparticle Effect on Fungi	Thyme and carvacrol AgNPs	Aspergillosis	NCT04431804
	Clinical and Radiographic Evaluation of the Synergistic Effect of Nano Silver Particles and Calcium Hydroxide Versus Triple Antibiotic Paste as Antibacterial Agents for Lesion Sterilization and Tissue Repair (LSTR) in Necrotic Primary Molars	Nano-silver particles and calcium hydroxide vs. triple antibiotic paste	Root canal infection	NCT05681221
	Effect of Metallic Nanoparticles on Nosocomial Bacteria	AgNPs and CuNPs	Nosocomial infections	NCT04775238
	Evaluation of the Antimicrobial Fiber Reinforced Composite Resin Space Maintainer Modified With Silver Nano Particles	Fiber reinforced composite resin space maintainer modified with silver nano particles	Dental caries in children	NCT05902975
AuNPs	Gold Factor on Knee Joint Health and Function	Dietary supplement: Gold factor (AuNPs)	Knee arthritis Knee osteoarthritis Knee pain chronic Knee discomfort Rheumatoid arthritis Knee pain swelling	NCT05347602
	Diagnostic and Prognostic Accuracy of Gold Nanoparticles in Salivary Gland Tumors	CD24-Gold nanocomposites	Carcinoma ex pleomorphic adenoma of salivary glands Pleomorphic adenoma of salivary glands	NCT04907422
	Plasmonic Photothermal and Stem Cell Therapy of Atherosclerosis Versus Stenting	Stenting and micro-infusion of NP	Coronary artery disease Atherosclerosis	NCT01436123
	Enhanced Epidermal Antigen Specific Immunotherapy Trial -1	C19-A3 GNP drug	Type 1 diabetes	NCT02837094
	NU-0129 in Treating Patients with Recurrent Glioblastoma or Gliosarcoma Undergoing Surgery	NU-0129 drug	Gliosarcoma Recurrent glioblastoma	NCT03020017
	Plasmonic Nanophotothermal Therapy of Atherosclerosis	Transplantation of NPs	Stable angina Heart failure Atherosclerosis Multivessel coronary artery disease	NCT01270139
	Effect of Nano Care Gold on Marginal Integrity of Resin Composite	Nano Care Gold (silver and gold NPs) suspended in 70% isopropyl alcohol, for cavity pre-treatment.	Caries class ii	NCT03669224
	A Phase-I Study of a Nanoparticle-based Peptide Vaccine Against Dengue Virus	Nanoparticle-based peptide vaccine	Dengue fever	NCT04935801
	A Phase-I Study of a Nanoparticle-based Peptide Vaccine Against SARS-CoV-2	Nanoparticle-based peptide vaccine	Coronavirus SARS-CoV-2 infection COVID-19	NCT05113862
	Diagnosis of Gastric Lesions from Exhaled Breath and Saliva	Chemical nanosensors based on organically functionalized AuNPs and carbon nanotubes	Stomach diseases	NCT01420588
	Exploratory Study Using Nanotechnology to Detect Biomarkers of Parkinson’s Disease from Exhaled Breath	Combinations of nanomaterial-based sensors	Parkinson’s disease Parkinsonism	NCT01246336