Table 3.
ECG disturbances in rats at 15 min, 30 min, and 60 min following application of 0.1 mL of sodium laurate (10 mg/kg) into inferior caval vein * p ˂ 0.05, at least vs. control.
| ECG Changes in Rats at 15 min, 30 min, and 60 min Following Application of 0.1 mL of Sodium Laurate (10 mg/kg) into the Inferior Caval Vein | ||||||
|---|---|---|---|---|---|---|
| Assessment | 15 min | 30 min | 60 min | |||
| Medication Application | Intragastric | Intraperitoneal | Intragastric | Intraperitoneal | Intragastric | Intraperitoneal |
| PQ Interval, msec Means ± SD | ||||||
| Control | 60 ± 5 | 62 ± 5 | 70 ± 5 | 73 ± 5 | 80 ± 5 | 84 ± 5 |
| BPC 157 10 μg/kg | 50 ± 5 * | 50 ± 5 * | 60 ± 5 * | 60 ± 5 * | 60 ± 5 * | 60 ± 5 * |
| BPC 157 10 ng/kg | 50 ± 5 * | 50 ± 5 * | 60 ± 5 * | 60 ± 5 * | 60 ± 5 * | 60 ± 5 * |
| QTc interval, msec, Means ± SD | ||||||
| Control | 350 ± 10 | 352 ± 12 | 360 ± 10 | 363 ± 10 | 380 ± 10 | 383 ± 10 |
| BPC 157 10 μg/kg | 235 ± 10 * | 225 ± 10 * | 250 ± 10 * | 254 ± 10 * | 274 ± 10 * | 272 ± 10 * |
| BPC 157 10 ng/kg | 230 ± 10 * | 227 ± 10 * | 252 ± 10 * | 250 ± 10 * | 270 ± 10 * | 276 ± 10 * |
| Heart frequency, beats/min, Means ± SD | ||||||
| Control | 100 ± 10 | 110 ± 10 | 75 ± 9 | 70 ± 9 | 55 ± 5 | 50 ± 5 |
| BPC 157 10 μg/kg | 280 ± 8 * | 290 ± 10 * | 260 ± 10 * | 265 ± 8 * | 235 ± 10 * | 237 ± 8 * |
| BPC 157 10 ng/kg | 282 ± 9 * | 285 ± 10 * | 268 ± 11 * | 270 ± 9 * | 230 ± 10 * | 232 ± 11 * |