Table 4.
Lesions were scored microscopically (heart, lung, liver, kidney, gastrointestinal tract) or macroscopically (stomach) in rats at 15 min, 30 min, and 60 min following application of 0.1 mL of sodium laurate (10 mg/kg) into inferior caval vein. * p ˂ 0.05, at least vs. control.
| Lesions Scored Microscopically (Heart, Lung, Liver, Kidney) or Macroscopically (Stomach) in Rats at 15 min, 30 min, and 60 min Following Application of 0.1 mL of Sodium Laurate (10 mg/kg) into Inferior Caval Vein | ||||||
|---|---|---|---|---|---|---|
| Assessment | 15 min | 30 min | 60 min | |||
| Medication Application | Intragastrical | Intraperitoneal | Intragastrical | Intraperitoneal | Intragastrical | Intraperitoneal |
| Heart (Scored 0–3, Min/Med/Max) | ||||||
| Control | 2/3/3 | 2/3/3 | 2/3/3 | 2/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/1/1 * | 0/1/1 * | 0/1/1 * | 0/1/1 * | 0/1/1 * | 0/1/1 * |
| BPC 157 10 ng/kg | 0/1/1 * | 0/1/1 * | 0/1/1 * | 0/1/1 * | 0/1/1 * | 0/1/1 * |
| Lung (scored 0–3, Min/Med/Max) | ||||||
| Control | 2/3/3 | 2/3/3 | 3/3/3 | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| Liver (scored 0–3, Min/Med/Max) | ||||||
| Control | 3/3/3 | 3/3/3 | 3/3/3 | 3/3/3 | 3/3/3 | 3/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/1/1 * | 0/1/1 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/1/1 * | 0/1/1 * |
| Kidney (scored 0–3, Min/Med/Max) | ||||||
| Control | 2/2/2 | 2/2/2 | 2/2/2 | 2/2/2 | 2/3/3 | 2/3/3 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| Stomach (sum of longest diameters, mm, Means ± SD) | ||||||
| Control | 4 ± 1 | 4 ± 1 | 5 ± 1 | 5 ± 1 | 6 ± 1 | 6 ± 1 |
| BPC 157 10 μg/kg | 0 ± 0 * | 0 ± 0 * | 0 ± 0 * | 0 ± 0 * | 0 ± 0 * | 0 ± 0 * |
| BPC 157 10 ng/kg | 0 ± 0 * | 0 ± 0 * | 0 ± 0 * | 0 ± 0 * | 0 ± 0 * | 0 ± 0 * |
| Stomach (scored 0–15, Min/Med/Max) | ||||||
| Control | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| Small intestine (scored 0–15, Min/Med/Max) | ||||||
| Control | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| Large intestine (scored 0–15, Min/Med/Max) | ||||||
| Control | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 | 5/5/5 |
| BPC 157 10 μg/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |
| BPC 157 10 ng/kg | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * | 0/0/0 * |