Table 1.

Estimated parameters of the PopPK model of AVA., i.e., estimated population parameters, inter-individual variability, and residual error parameter.

Stochastic Approximation
		S.E.	R.S.E. (%)
Fixed Effects
Tlag_pop h	0.17	0.013	7.66
Tk0_pop h	1.35	0.12	8.87
β_Tk0_Formulation#2	−0.4	0.12	29.0
β_Tk0_Formulation#3	−0.68	0.13	18.5
Cl/F_pop L/h	56.15	2.15	3.83
V1/F_pop L	208.34	11.07	5.31
β_V1/F_Formulation#2	−1.26	0.068	5.44
β_V1/F_Formulation#3	−1.24	0.071	5.71
Q/F_pop L	14.63	1.7	11.6
V2/F_pop L	76.15	11.38	14.9
Standard Deviation of the Random Effects (omega)
ω_Tlag	0.38	0.082	21.4
ω_Tk0	0.24	0.036	14.8
ω_Cl/F	0.21	0.027	13.0
ω_V1/F	0.15	0.034	22.4
ω_Q/F	0.47	0.1	21.1
ω_V2/F	0.24	0.093	39.1
Correlations
corr_V1/F_Cl/F	0.72	0.14	19.0
Error Model Parameters
b	0.14	0.0076	5.28

Abbreviations: S.E.—standard error, R.S.E—relative standard error, Tlag_pop—estimated lag time before absorption, Tk0_pop—estimated zero-order input, β—estimated coefficient accounting for categorical covariate (i.e., formulation when a population parameter shows dependency on a covariate), CL/F—estimated apparent clearance when the ratio of clearance to bioavailability (F) is assumed constant, V1/F, V2/F—estimated apparent volume of distribution accounting for the first and second compartment, respectively, Q/F—estimated intercompartmental clearance between compartments, corr—correlation between population parameters, b—parameter of the error model for the observations.