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. 2023 Sep 28;15(10):2402. doi: 10.3390/pharmaceutics15102402
ADCC antibody-dependent cellular cytotoxicity
ADCP antibody-dependent cellular phagocytosis
Ang-2 angiopoietin-2
ART-Ig asymmetric reengineering technology-immunoglobulin
BiTE bispecific T-cell engager
C1q complement component 1q
CD cluster of differentiation
CDC complement-dependent cytotoxicity
CDR complementarity-determining region
CH constant region of heavy chain
CHO Chinese hamster ovarian
CTLA-4 cytotoxic T-lymphocyte-associated protein-4
Fab fragment antigen binding
Fc fragment crystallizable
Fcγ fragment crystallizable gamma
FcRn neonatal Fc receptor
FcγR Fc gamma receptor
FIXa activated coagulation factor IXa
FUT fucosyltransferase
FVIII coagulation factor VIII
FX coagulation factor X
FXa activated coagulation factor X
GlcNAc N-acetylglucosamine
GnTIII N-acetylglucosaminyltransferase III
HAMA human anti-mouse antibody
HER2 human epidermal growth factor receptor-2
HIV human immunodeficiency virus
IgG immunoglobulin G
IL interleukin
ITAM tyrosine-based activation motif
ITIM immunoreceptor tyrosine-based inhibitory motif
IVIg intravenous immunoglobulin G
κ kappa light chain
kDa kilodalton (a unit of molecular weight)
KiH “knob-into-holes” design
mAbs monoclonal antibodies
MAC membrane attack complex
MHC major histocompatibility complex 4
NET neutrophil extracellular trap
NK cells natural killer cells
PD-1 programmed cell death protein-1
PD-L1 programmed cell death ligand 1
scFv single-chain variable fragment
sdAb single-domain antibody
SEED strand-exchange engineered domain
TNFα tumor necrosis factor-alpha
VEGF vascular endothelial growth factor
VH variable region of heavy chain