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. 2023 Oct 11;16(10):1440. doi: 10.3390/ph16101440

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Proposed mechanism of canthin-6-one on inhibition of RA-FLS migration and invasion. Cant limits synovial fibroblast migration and invasion and reduces joint damage by up-regulating the expression of Hippo pathway regulators, MST1 and LATS1, thus down-regulating the expression and activation of YAP (indicated by phosphorylation of YAP on Ser397 and Ser127) and TAZ, which results in reduced production of TNF-α-induced MMPs (including MMP1 and MMP3) and pro-inflammatory cytokines (IL-6 and IL-1β).