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. 2023 Sep 27;16(10):1366. doi: 10.3390/ph16101366

Figure 1.

Figure 1

Schematic of D-series resolvins biosynthesis and enzymatic pathway. RvDs are synthesized from DHA via several types of LOX and LTA4H. 17(S)-HDHA converted from DHA is oxidized into two hydroperoxyl intermediates via LOX5, which can be converted into three types of RvDs. RvD1, RvD2, and RvD5 are synthesized from 7(S)-Hp-17(S)-HDHA. RvD3, RvD4, and RvD6 are synthesized from 4(S)-Hp-17(S)-HDHA. 17(S)-HDHA, 17(S)-hydroxy DHA; 4(S)-Hp-17(S)-HDHA, 4(S)-hydroperoxy-17(S)-HDHA; 7(S)-Hp-17(S)-HDHA, 7(S)-hydroperoxy-17(S)-HDHA DHA, docosahexaenoic acid; LOX, lipoxygenase; LTA4H, leukotriene A4 hydrolase; RvDs, D-series Rvs; RvDn, Rv Dn (n = 1~6).