Table 1.
Summary of recent studies on polysaccharide-based nanogels for overcoming mucus gel barrier.
| Author | Type of Nanogel | Function and Mechanism | Size/Zeta Potential | Loaded Cargo | Year | Ref. |
|---|---|---|---|---|---|---|
| Mahmood et al. | Thiolated chitosan | Mucosal adhesion | 26.30 ± 26.86 nm 0.03 mV |
Curcumin | 2017 | [53] |
| Jin et al. | Thiolated chitosan | Mucosal adhesion | 196.72 ± 0.45 nm 17.12 ± 0.50 mV |
Bovine serum albumin | 2022 | [54] |
| Guaresti et al. | Thiolated chitosan | Mucosal adhesion | 5–12 nm 36 ± 4 to −7 ± 1 mV |
/ | 2020 | [55] |
| Shtenberg et al. | PEG modified alginate | Mucosal adhesion | / | Ibuprofen sodium | 2017 | [57] |
| Tian et al. | Thiolated hyaluronic acid | Mucus penetration | Average 100 nm −26.2 ± 1.0 mV |
INS | 2018 | [61] |
| Cao et al. | Chitosan | Mucus penetrationMuco-adhesive | / | Oral Vaccination | 2021 | [63] |
| Ways et al. | Chitosan | Mucus penetrating | 145 ± 21 nm 15.0 ± 0.3 mV |
/ | 2022 | [65] |