Table 3.
Summary of recent studies on polysaccharide-based nanogels for overcoming ocular barrier.
| Author | Type of Nanogel | Function and Mechanism | Size/Zeta Potential | Loaded Cargo | Type of Study | Year | Ref. |
|---|---|---|---|---|---|---|---|
| Buosi et al. | Chitosan | ARPE-19 cell targeting | ~140 nm, 32 ± 2 mV |
Resveratrol | In vitro | 2020 | [107] |
| Laradji et al. | Hyaluronic acid | Redox-responsive release, penetration |
~80 nm, −7.56~−2.24 mV |
Fluorescein | In vitro In vivo |
2021 | [108] |
| Zheng et al. | Catechol modified quaternized chitosan | Thermosensitive, tissue adhesive | / | / | In vitro In vivo |
2020 | [110] |
| Chaharband et al. | Chitosan, hyaluronic acid | Overcoming vitreous and retina barriers | / | siRNA | In vitro | 2020 | [112] |
| Silva et al. | Chitosan, hyaluronic acid | Enhanced muco-adhesion and permeation | ≤300 nm, +30 mV |
Erythropoietin | In vitro Ex vivo |
2020 | [113] |
| Lavikainen et al. | Gellan | Enhanced muco-adhesion and permeation | / | / | In vitro | 2021 | [116] |
| Nagai et al. | Methylcellulose | Prolonged pre-corneal and pre-conjunctival contact time | ~93 nm | Tranilast | In vitro In vivo |
2020 | [119] |