Table 4.
Summary of recent studies on polysaccharide-based nanogels for overcoming BBB.
| Author | Type of Nanogel | Function and Mechanism | Size/Zeta Potential | Loaded Cargo | Type of Study | Year | Ref. |
|---|---|---|---|---|---|---|---|
| Vashist et al. | Chitosan, hydroxyethyl cellulose | Auto-fluorescence, promote penetration | / | Bioactives | In vitro | 2020 | [130] |
| Pourtalebi Jahromi et al. | Chitosan | Enhanced pernetration | <200 nm, 22.8 ± 6.55 mV | Methotrexate | In vitro | 2019 | [132] |
| Bostanudin et al. | Guar, pullulan, chitosan | Enhanced permeation | 120–200 nm, −23~−32 mV | Doxorubicin | In vitro | 2020 | [133] |
| Gadhave et al. | Gellan, Carbopol | Enhanced permeation, in situ gel, nose-to-brain delivery | 117.80 nm, −21.86 mV | Teriflunomide | In vitro | 2021 | [135] |
| Ourani-Pourdashti et al. | Chitosan, Poloxamer 407 | Temperature-sensitive in situ gel, nose-to-brain delivery | 130.5 nm, −38.5 mV |
Methotrexate | In vitro In vivo |
2022 | [136] |