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. Author manuscript; available in PMC: 2024 Sep 1.
Published in final edited form as: J Invest Dermatol. 2023 Sep;143(9):1667–1677. doi: 10.1016/j.jid.2023.03.1679

Figure 1. The many scales of biological variation in skin that we predict will have a significant effect on transcriptional heterogeneity.

Figure 1.

a) The spatial scale represents how skin composition and characteristics vary across anatomical regions. b) The temporal scale represents changes to skin across the human lifespan. c) The gender scale represents gender-specific differences between skin sites and function. d) The ancestral origin scale, which affects skin characteristics and proclivity to disease. e) The wound response scale, where unwounded skin is distinct from skin that is permanently altered after the innate, acute wound repair program. For each scale, we include notable examples that illustrate why these factors need to be considered when generating a high-quality single-cell skin atlas.