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. 2023 Oct 15;16(10):1465. doi: 10.3390/ph16101465

Figure 4.

Figure 4

Changes in the serotonergic receptors in the spinal cord after oxaliplatin and [6]-Shogaol injections in mice. The gene (A,B) and protein (C,D) expressions of 5−hydroxytryptamine (5−HT)1A and 3 receptors were measured using reverse transcription–quantitative polymerase chain reaction (RT−qPCR) and Western blot, respectively. The lumbar 4–5 spinal cords were sampled for the experiment. The control group received 5% glucose. The OXA group received 6 mg/kg of oxaliplatin and 10% of dimethyl sulfoxide (DMSO). The [6]-Shogaol group received 6 mg/kg of oxaliplatin with 10 mg/kg of [6]-shogaol. All drugs were injected intraperitoneally. Data are presented as mean ± SD. Control: n = 6; OXA: n = 6; OXA + [6]-Shogaol: n = 6. 5−HT1AR: 5−HT1A Receptor; 5−HT3R: 5−HT3 Receptor; NS: non-significant; OXA: oxaliplatin. * p < 0.05, ** p < 0.01: Control vs. OXA; # p < 0.05, ### p < 0.001: OXA vs. [6]-Shogaol with one-way ANOVA followed by Tukey’s multiple comparisons test.