Figure 4.

H₂O₂ and pH dual-responsive nanoplatforms for synergistic phototherapy with hypoxia relief and additional benefits including controlled drug release. (A) Schematic illustration of the construction of MnO₂-based H₂O₂ and pH dual-responsive NPs for hypoxia relief in nucleus-targeted PTT and hypoxia-relieved PDT. Adapted with permission from ref. [66]. (B) Schematic illustration of the facile preparation of H₂O₂ and pH dual-responsive Ce6/iPMC-MnO₂ and their application in dual-modal imaging-guided PDT and PTT. Adapted with permission from ref. [38]. (C) Schematic illustration of the fabrication of the intelligent ZIF-8-gated PDA nanohybrids for hypoxia relief with CAT in the combined PDT and PTT. Adapted with the open access figure from ref. [70]. (D) Schematic illustration of the fabrication of tumor-targeting NPs with dual-responsiveness for hypoxia relief and pH-triggered PS release. Adapted with permission from ref. [71]. (E) Schematic diagrams of the synthesis and application of UCTTD-PC4 nanoplatform for tumor-targeted PTT/PDT for hypoxic pancreatic cancer triggered by TME and guided by multimodal imaging. Adapted with permission from ref. [74].