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. 2023 Oct 17;15(10):2480. doi: 10.3390/pharmaceutics15102480

Figure 6.

Figure 6

TME-responsive drug release including low pH/GSH/enzyme-induced protonation, NP self-immolation, bond cleavage and hypoxia-activated chemotherapy in tri-modal synergistic PDT/PTT/chemotherapy. (A) Schematic illustration of preparing PGP/CaCO3@IR820/DTX-HA nanoprobes. Adapted with permission from ref. [87]. (B) Schematic illustration of AZGL nanocomposite preparation and its application in breast cancer treatment. Adapted with the open access figure from ref. [88]. (C) Schematic illustration of the preparation process for GNRs-MPH-ALA/DOX-PEG and their application in tri-modal PDT/PTT/chemotherapy of breast cancer. (I) Simultaneous release of ALA and DOX provoked by acidic TME. (II) Hyperthermia generated from the GNRs-MPH-PEG for PTT. (III) ALA was metabolized to PpIX for PDT. (IV) DOX release for chemotherapy. Adapted with permission from ref. [89]. (D) Schematic illustration of IR&DOX@NC fabrication and intratumor process for multi-modal tumor ablation. Adapted with permission from ref. [90]. (E) Schematic illustration for the preparation of ICG-PDA-TPZ NPs and their combined PDT/PTT/Hypoxia-activated chemotherapy. Adapted with the open access figure from ref. [36].