Table 1.

Summary of phototherapies enhanced by hypoxia relief via catalytic H₂O₂ decomposition in the TME.

PS	Photothermal Agent	H2O2-Decomposition Entity	Function/Purpose	Tumor Model In Vitro	Tumor Model In Vivo	Ref.
MB	APMs	CAT	Controlled Release and hypoxia relief	PC-3 cells	/	[40]
Ce6	GNS	CAT	Hypoxia relief, in vivo CT imaging	HeLa and MCF-7 cells	BALB/c nude mice with HeLa tumors	[41]
Ce6	Pd@Pt	Pt	Hypoxia relief and tumor imaging	4T1 cells	Balb/c mice with 4T1 tumors	[42]
Ce6	PTAs	CAT	Hypoxia relief	HeLa cells	Balb/c mice with U14 tumors	[43]
Pt	Pd@Pt	Pt	Hypoxia relief	LM8 and L929 cells	Female Balb/c mice with LM8 tumors	[44]
ICG	GNSs	Pt	Hypoxia relief	4T1 cells	Mice with 4T1 tumors	[45]
ZnPc	PB	PB	Hypoxia relief	4T1 cells	Mice with 4T1 tumors	[46]
IR808-Br2	RuO2@BSA	RuO2@BSA	Hypoxia relief and NIRF imaging	4T1 cells	Mice with 4T1 tumors	[47]
ICG	Rh	Au@Rh	Hypoxia relief	MDA-MB-231 cells	Balb/c nude mice with MDA-MB-231 tumors	[48]
Ce6	MPDAand Rh NPs	Rh NPs	Hypoxia relief	4T1 cells	Female BALB/c mice with 4T1 tumors	[49]
BSA-IrO2	BSA-IrO2	BSA-IrO2	Hypoxia relief and low-temperature PTT	L929 cells	Mice with MDA-MB-231 tumors	[50]
Ce6	PDA and IrO2 NPs	IrO2	Hypoxia relief	HT29 cells	Balb/c nude mice with HT29 tumors	[51]