Table 3.

Summary of phototherapies responsive to both lower pH and enriched H₂O₂ in the TME.

PS	Photothermal Agent	pH-Responsive Entity	H2O2-Responsive Entity	Function/Purpose	Tumor Model In Vitro	Tumor Model In Vivo	Reference
Ce6	Pd@Au nanoplates	MnO2	MnO2	Hypoxia relief	MCF-7 cells	BALB/c mice with MCF-7 tumors	[66]
Ce6	MC	MnO2	MnO2	Hypoxia relief	4T1 cells	BALB/c mice with 4T1 tumors	[38]
Ce6	Au/Ag alloy	MnO2	MnO2	Hypoxia relief	HeLa cells	Mice with HeLa tumors	[67]
ICG	AuNRs	MnO2	MnO2	Modulate the tumor microenvironment	MCF-7 cells	BALB/c mice with 4T1 tumors	[68]
MnPcE4	Bi	MnO2	Mn2+	Hypoxia relief	HeLa cells	Kunming mice with U14 tumors	[69]
MB	PDA	ZIF-8	CAT	Hypoxia relief and lowpH-triggered drug release	HeLa cells	Mice with HeLa tumors	[70]
Ce6	MnO2@Ce6@PDA-FA NPs	PDA	MnO2	Hypoxia relief and low pH-triggered drug release	MCF-7 and NP69 cells	BALB/c nude mice with MCF-7 tumors	[71]
Ce6	CuS	PDA	MnO2	Hypoxia relief and low pH-triggered drug release	4T1 cells	BALB/c mice with 4T1 tumors	[72]
ICG	ICG	ZIF-8	MnO2	Hypoxia relief and low pH-triggered drug release	4T1 cells	BALB/c mice with 4T1 tumors	[73]
PC4	TA/Fe3+ nanofilms	UCTTD	Fe3+	Hypoxia relief and low pH-triggered drug release	Capan-1 cells	BALB/c-nude mice with Capan-1 tumors	[74]
IR780	IR780	MnO2	MnO2	Hypoxia relief and enhanced intratumoral drug penetration	HepG2 and 3T3 cells	Nude mice with HepG2 tumors	[75]
/	Cu2–xS	MnO2	MnO2	Hypoxia relief	A549 and MCF-7 cells	Female BALB/c nude mice with B16 tumors	[76]
/	Au@Cu2−xS	Au@Cu2−xS/DOX-PEG	/	Drug delivery	MCF-7 cells	BALB/c nude mice with A549 tumors	[77]