Table 3.
Gene expression of inflammasome-related molecular biomarkers in EA.hy926 cells treated with ipconazole at 20 and 50 µM or DMSO (0.1%) as a carrier control.
| Gene | Control | Vehicle (Veh) | Ipconazole | |
|---|---|---|---|---|
| 20 µM | 50 µM | |||
| Fold Change | ||||
| NLRP3 | 1.00 | 0.97 | 1.52 | 1.59 * |
| CASP1 | 1.00 | 1.01 | 0.96 | 2.07 *** |
| IL1β | 1.00 | 0.97 | 2.14 ** | 2.41 ** |
| NFκB | 1.00 | 1.02 | 1.76 | 2.31 ** |
| IL6 | 1.00 | 0.96 | 1.37 | 3.34 *** |
| TNFα | 1.00 | 1.00 | 1.30 | 1.56 * |
Data for gene expression represent fold change mean. * p < 0.05, ** p < 0.01 or *** p < 0.001 compared to vehicle, for three independent experiments. The red color represents up-regulation.