Table 4.
Comparison with concentrations at which toxicity was detected in previous reports.
Toxicity Detection Concentration (µM) | Toxicity Detection (This Work) |
Reference | |||||
---|---|---|---|---|---|---|---|
Compound | Concentration Tested (µM) | Cell | Axon | Cell | Axon | MANOVA | |
Previous Report |
Previous Report |
||||||
Paclitaxel | 0.1 | over 0.1 | Over 0.01 | ◎ | ○ | ◎ | [31] |
1 | ◎ | ◎ | ◎ | ||||
Vincristine | 0.003 | 24 h no effect |
24 h Over 0.001 |
○ | ◎ | ◎ | [23] |
0.03 | 72 h 0.1 |
○ | ◎ | ◎ | |||
Oxaliplatin | 10 | Over 10 | Over 3.3 | ◎ | ○ | ◎ | [29] |
100 | ◎ | ○ | ◎ | ||||
Suramin | 10 | 48 h 300 |
48 h 200 |
○ | ○ | ◎ | [33,38] |
100 | 8 day Over 100 |
○ | ○ | ◎ | |||
Bortezomib | 0.01 | 24 h no effect |
24 h 1 |
○ | ○ | ◎ | [23] |
72 h 0.012 | 72 h 0.03 |
○: Over toxicity prediction line; ◎: p < 0.05.