Table 5.
Hazard and exposure specifications of the cosmetic ingredients incorporated in the developed formulation. Product type: anti-ageing cream. Ingredients.
| Ingredient Id | CAS | INCI | Conc. % | Annex | Mutagenicity | Skin Sensitization |
Dermal Abs. | MoS | TTC |
|---|---|---|---|---|---|---|---|---|---|
| Jojoba Esters | 68953 | Jojoba Esters | 3.75 | - | - | - | - | - | |
| Helianthus Annuus (Sunflower) Seed Wax | 8001-21-6 | Helianthus Annuus (Sunflower) Seed Wax | 0.5 | - | - | - | - | - | |
| Acacia Decurrens Flower Wax | 98903-76-5 | Acacia Decurrens Flower Wax | 0.05 | - | - | - | - | - | |
| Polyglycerin-3 | 25618-55-7 | Polyglycerin-3 | 0.05 | - | NM (e.v.) |
NS (e.v.) |
80% | 26,725.35 | 0.046 mg/kg bw/day |
| Octyldodecyl Myristate | 22766-83-2 | Octyldodecyl Myristate | 1.0 | - | NM (+++) |
S (+) |
80% | 1345.12 | 0.046 mg/kg bw/day |
| Caprylic/Capric Triglyceride | 65381-09-1 | Caprylic/Capric Triglyceride | 3.0 | - | - | - | - | - | |
| Hydrogenated Ethylhexyl Olivate | 22047-49-0 | Hydrogenated Ethylhexyl Olivate | 5.0 | - | - | - | - | - | |
| Hydrogenated Olive Oil Unsaponifiables | 111-01-3 | Hydrogenated Olive Oil Unsaponifiables | 2.5 | - | - | - | - | - | |
| Cetyl Alcohol | 36653-82-4 | Cetyl Alcohol | 0.5 | - | NM (+++) |
S (++) |
40% | 20,712.51 | 0.046 mg/kg bw/day |
| Glyceryl Stearate | 31566-31-1 | Glyceryl Stearate | 0.5 | - | NM (+++) |
S (+++) |
40% | 8983.43 | 0.046 mg/kg bw/day |
| PEG-75 Stearate | 9004-99-3 | PEG-75 Stearate | 0.25 | - | NM (+++) |
S (+++) |
40% | 10,347.97 | 0.046 mg/kg bw/day |
| Ceteth-20/Steareth-20 | 68439-49-6 | Ceteth-20/Steareth-20 | 0.25 | - | - | - | - | - | |
| Butyl Methoxydibenzoylmethane | 70356-09-1 | Butyl Methoxydibenzoylmethane | 2.0 | VI | NM (+++) |
S (+) |
40% | 51.11 | 0.0023 mg/kg bw/day |
| Octocrylene | 6197-30-4 | Octocrylene | 10.0 | VI | NM (e.v.) |
S (+) |
10% | 675.23 | 0.0023 mg/kg bw/day |
| Deionized Water | 7732-18-5 | Aqua | 59.2 | - | - | - | - | - | |
| Glycerine | 56-81-5 | Glycerine | 3.0 | - | NM (e.v.) |
NS (e.v.) |
80% | 445.42 | 0.046 mg/kg bw/day |
| Triethanolamine | 102-71-6 | Triethanolamine | 0.45 | III | NM (e.v.) |
S (+) |
80% | 5753.48 | 0.046 mg/kg bw/day |
| Carbomer | 9007-20-9 | Carbomer | 0.35 | - | NM (e.v.) |
S (++) |
80% | 1597.82 | 0.0023 mg/kg bw/day |
| Phenoxyethanol | 122-99-6 | Phenoxyethanol | 0.9 | V | NM (e.v.) |
NS (e.v.) |
80% | 460.28 | 0.046 mg/kg bw/day |
| Ethylhexylglycerin | 70445-33-9 | Ethylhexylglycerin | 0.1 | - | NM (+++) |
NS (+) |
80% | 9737.47 | 0.0023 mg/kg bw/day |
| Sodium Polyacrylate | 9003-04-7 | Sodium Polyacrylate | 0.65 | - | - | - | - | - | |
| Hydrogenated Polydecene | 68037-01-4 | Hydrogenated Polydecene | 0.45 | - | NM (e.v.) |
NS (+) |
40% | 682.82 | 0.046 mg/kg bw/day |
| Trideceth-6 | 78330-21-9 | Trideceth-6 | 0.06 | - | NM (+++) |
S (++) |
40% | 24,235.36 | 0.046 mg/kg bw/day |
| Hydrolysed Hyaluronic Acid | 9004-61-9 | Hydrolysed Hyaluronic Acid | 0.5 | - | NM (++) |
S (+) |
10% | 13,598,771.33 | 0.0023 mg/kg bw/day |
| Sucrose Palmitate | 26446-38-8 | Sucrose Palmitate | 0.25 | - | NM (+++) |
S (+) |
10% | 724,425.85 | 0.0023 mg/kg bw/day |
| Tocopheryl Acetate | 7695-91-2 | Tocopheryl Acetate | 0.09 | - | NM (+++) |
S (++) |
40% | 9153.78 | 0.0023 mg/kg bw/day |
| Glyceryl Linoleate | 2277-28-3 | Glyceryl Linoleate | 0.09 | - | NM (+++) |
S (+++) |
40% | 49,907.94 | 0.046 mg/kg bw/day |
| Sodium Hyaluronate | 9067-32-7 | Sodium Hyaluronate | 0.009 | - | - | - | - | - | |
| Potassium Sorbate | 24634-61-5 | Potassium Sorbate | 0.005 | V | NM (e.v.) |
S (+++) |
40% | 1,035,625.52 | 0.046 mg/kg bw/day |
| Citric Acid | 77-92-9 | Citric Acid | 0.009 | - | NM (e.v.) |
NS (++) |
80% | 752,796.19 | 0.046 mg/kg bw/day |
| Fructose | 57-48-7 | Fructose | 2.5 | - | NM (+++) |
NS (++) |
80% | 2120.28 | 0.046 mg/kg bw/day |
| Aesculus Hippocastanum (Horse Chestnut) Extract | 8053-39-2 | Aesculus Hippocastanum (Horse Chestnut) Extract | 0.5 | - | - | - | - | - | |
| Silica | 7631-86-9 | Silica | 0.9 | - | NM (++) |
S (+) |
40% | 3365.21 | 0.0023 mg/kg bw/day |
| CI 77891 | 13463-67-7 | CI 77891 | 0.24 | VI | NM (e.v.) |
S (+) |
10% | 4263.33 | 0.0023 mg/kg bw/day |
| CI 77491 | 1309-37-1 | CI 77491 | 0.02 | IV | - | - | - | - | |
| Ectoin | 96702-03-3 | Ectoin | 0.3 | - | M (++) |
S (+) |
40% | 3167.98 | 0.0023 mg/kg bw/day |
| Mannitol | 69-65-8 | Mannitol | 0.75 | - | NM (e.v.) |
S (+) |
40% | 18,652.44 | 0.046 mg/kg bw/day |
| Cellulose | 9004-34-6 | Cellulose | 0.3 | - | - | - | - | - | |
| Calcium Sodium Borosilicate | 65997-17-3 | Calcium Sodium Borosilicate | 0.25 | - | - | - | - | - | |
| CI 77492 | 51274-00-1 | CI 77492 | 0.05 | IV | - | - | - | - | |
| CI 77891 | 13463-67-7 | CI 77891 | 0.05 | VI | NM (e.v.) |
S (+) |
10% | 20,463.96 | 0.0023 mg/kg bw/day |
| Gold | 7440-57-5 | Gold | 0.01 | IV | NM (++) |
- | 10% | 107,207.95 | 0.0023 mg/kg bw/day |
| Tin Oxide | 18282-10-5 | Tin Oxide | 0.01 | - | NM (++) |
S (+) |
40% | 14,415.91 | 0.0023 mg/kg bw/day |
| Hydroxypropyl Methylcellulose | 9004-65-3 | Hydroxypropyl Methylcellulose | 0.001 | - | NM (++) |
S (+) |
80% | 2,614,954.43 | 0.046 mg/kg bw/day |
| Parfum | Parfum | 0.1 | - | - | - | - | - |
Non-mutagen—NM; mutagen—M; non-sensitizer—NS; sensitizer—S; low reliability—(+); moderate reliability—(++); good reliability—(+++); experimental value—(e.v.).
| Non-mutagen: experimental value | Non-mutagen: good (+++) / moderate reliability (++) | Mutagen: moderate reliabity (++) | MoS > 100 | MoS < 100 | |||||
| Non-sensitizer: experimental value | Non-sensitizer: low reliability (+) | Sensitizer: good relibility (+++) | Sensitizer: moderate reliability (++) | Sensitizer: low reliability (++) |