Table 3.
Mastoparan | MIC (μM) | EC50 (μM) | SI | Refs. | ||||
---|---|---|---|---|---|---|---|---|
E. coli | S. aureus | B. subtilis | HRBC | RRBC | E. coli | S. aureus | ||
EMP-AF | 13 | 3.3 | ND | 110.6 ± 9.8 | 122.1 ± 13.1 | 8.5 | 33.5 | [18] |
EMP-EF | 30 | 30 | ND | 125.2 ± 20.6 | 216.7 ± 1.6 | 4.2 | 4.2 | [13] |
Eumenitin-R | 30 | 60 | ND | - | - | >13.3 | 6.7 | [13] |
EMP-ER | 30 | 30 | ND | - | 230.6 ± 3.7 | >13.3 | 13.3 | [13] |
Eumenitin-F | 30 | >60 | ND | 157.1 ± 2.6 | 207.1 ± 2.0 | 5.2 | / | [13] |
Eumenitin | 6 | 6 | >60 | - | - | >66.7 | >66.7 | [19] |
EMP-OD (OdVP1) | 97 | 97 | 10 | - | 189.8 ± 32.0 | >4.1 | >4.1 | [20] |
OdVP3 | >200 | >200 | 10 | - | - | / | / | [20] |
EpVP1 | 25 | 100 | 5 | - | - | >16.0 | >4.0 | [20] |
EpVP2a | 100 | 50 | 5 | 151.9 ± 6.3 | 238.8 ± 7.6 | 1.5 | 3.0 | [20] |
EpVP2b | 200 | 25 | 5 | 34.1 ± 3.5 | 50.6 ± 2.6 | 0.2 | 1.4 | [20] |
Mastoparan-L | 50 | 5 | 8 | 82.9 ± 3.8 | 242.5 ± 2.6 | 1.7 | 16.6 | [21] |
MP-VB1 | 10.3 | 2.5 | ND | - | - | >38.8 | >160.0 | [22] |
Mastoparan-X(V) | 4.8 | 2.4 | ND | 349.4 ± 4.9 | 312.1 ± 4.7 | 72.8 | 145.6 | [23] |
Mastoparan-A | 5 | 20 | ND | - | 183.0 ± 3.4 | >80.0 | >20.0 | [23] |
Mastoparan-B | 10 | 60 | ND | - | - | >40.0 | >6.7 | [23] |
Mastoparan-C | 4 | 4 | ND | 30.2 ± 1.3 | 64.4 ± 10.7 | 7.6 | 7.6 | [22] |
Mastoparan-T(D) | 5.3 | 15.9 | ND | - | - | >75.5 | >25.2 | [23] |
Protonectarina-MP | 5 | 2.5 | 2.5 | 85.2 ± 5.9 | 326.5 ± 26.4 | 17.0 | 34.1 | [24] |
Polybia-MP I | 4.8 | 9 | 2.4 | 176.6 ± 7.0 | 51.4 ± 2.2 | 36.8 | 19.6 | [25] |
Polybia-MP II | 5 | 2.5 | 5 | 23.3 ± 1.4 | 29.1 ± 1.5 | 4.7 | 9.3 | [26] |
Polybia-MP III | ND | 19 | ND | 38.5 ± 5.9 | 74.8 ± 10.4 | / | 2.0 | [26] |
Parapolybia-MP | 2.4 | 1.8 | 2.2 | - | - | >166.7 | >222.2 | [24] |
Agelaia-MPI | 243.8 | 121.8 | 151.2 | 3.7 ± 0.14 | 7.0 ± 0.7 | 0.02 | 0.04 | [12] |
Mastoparan-like peptide 12b | 10 | 2.5 | ND | - | - | >40.0 | >160.0 | [27] |
Mastoparan-M | 13.5 | 3.38 | ND | - | - | >29.6 | >118.3 | [23] |
Mastoparan-AF | 2.64 | 10.6 | ND | 227.0 ± 3.1 | 107.3 ± 15.7 | 86.0 | 21.4 | [23] |
PDD-A | 7.5 | ND | 11.8 | 353.5 ± 44.8 | - | 47.1 | / | [28] |
PDD-B | 70 | ND | 15.5 | 48.5 ± 3.4 | 55.6 ± 4.1 | 0.7 | / | [28] |
MP | 65 | ND | 9 | 123.6 ± 15.3 | - | 1.9 | / | [28] |
EMP-EM1 | 7 | 34 | 68 | - | - | >57.1 | >11.8 | [29] |
EMP-EM2 | 3 | 17 | 68 | - | - | >133.3 | >23.5 | [29] |
Dominulin A | 1 | ND | 4 | - | - | >400.0 | / | [30] |
Dominulin B | 1 | ND | 4 | - | - | >400.0 | / | [30] |
SI: selectivity index, SI = EC50 of hemolytic activity on HRBC/MICE. coli or MIC S. aureus. ND means no data; -: the hemolytic activity was too low to calculate the EC50. /: the value of SI is unpredictable.