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. 2023 Sep 28;15(10):591. doi: 10.3390/toxins15100591

Table 3.

The statistics of antibacterial activity and hemolytic activity of 34 mastoparans.

Mastoparan MIC (μM) EC50 (μM) SI Refs.
E. coli S. aureus B. subtilis HRBC RRBC E. coli S. aureus
EMP-AF 13 3.3 ND 110.6 ± 9.8 122.1 ± 13.1 8.5 33.5 [18]
EMP-EF 30 30 ND 125.2 ± 20.6 216.7 ± 1.6 4.2 4.2 [13]
Eumenitin-R 30 60 ND - - >13.3 6.7 [13]
EMP-ER 30 30 ND - 230.6 ± 3.7 >13.3 13.3 [13]
Eumenitin-F 30 >60 ND 157.1 ± 2.6 207.1 ± 2.0 5.2 / [13]
Eumenitin 6 6 >60 - - >66.7 >66.7 [19]
EMP-OD (OdVP1) 97 97 10 - 189.8 ± 32.0 >4.1 >4.1 [20]
OdVP3 >200 >200 10 - - / / [20]
EpVP1 25 100 5 - - >16.0 >4.0 [20]
EpVP2a 100 50 5 151.9 ± 6.3 238.8 ± 7.6 1.5 3.0 [20]
EpVP2b 200 25 5 34.1 ± 3.5 50.6 ± 2.6 0.2 1.4 [20]
Mastoparan-L 50 5 8 82.9 ± 3.8 242.5 ± 2.6 1.7 16.6 [21]
MP-VB1 10.3 2.5 ND - - >38.8 >160.0 [22]
Mastoparan-X(V) 4.8 2.4 ND 349.4 ± 4.9 312.1 ± 4.7 72.8 145.6 [23]
Mastoparan-A 5 20 ND - 183.0 ± 3.4 >80.0 >20.0 [23]
Mastoparan-B 10 60 ND - - >40.0 >6.7 [23]
Mastoparan-C 4 4 ND 30.2 ± 1.3 64.4 ± 10.7 7.6 7.6 [22]
Mastoparan-T(D) 5.3 15.9 ND - - >75.5 >25.2 [23]
Protonectarina-MP 5 2.5 2.5 85.2 ± 5.9 326.5 ± 26.4 17.0 34.1 [24]
Polybia-MP I 4.8 9 2.4 176.6 ± 7.0 51.4 ± 2.2 36.8 19.6 [25]
Polybia-MP II 5 2.5 5 23.3 ± 1.4 29.1 ± 1.5 4.7 9.3 [26]
Polybia-MP III ND 19 ND 38.5 ± 5.9 74.8 ± 10.4 / 2.0 [26]
Parapolybia-MP 2.4 1.8 2.2 - - >166.7 >222.2 [24]
Agelaia-MPI 243.8 121.8 151.2 3.7 ± 0.14 7.0 ± 0.7 0.02 0.04 [12]
Mastoparan-like peptide 12b 10 2.5 ND - - >40.0 >160.0 [27]
Mastoparan-M 13.5 3.38 ND - - >29.6 >118.3 [23]
Mastoparan-AF 2.64 10.6 ND 227.0 ± 3.1 107.3 ± 15.7 86.0 21.4 [23]
PDD-A 7.5 ND 11.8 353.5 ± 44.8 - 47.1 / [28]
PDD-B 70 ND 15.5 48.5 ± 3.4 55.6 ± 4.1 0.7 / [28]
MP 65 ND 9 123.6 ± 15.3 - 1.9 / [28]
EMP-EM1 7 34 68 - - >57.1 >11.8 [29]
EMP-EM2 3 17 68 - - >133.3 >23.5 [29]
Dominulin A 1 ND 4 - - >400.0 / [30]
Dominulin B 1 ND 4 - - >400.0 / [30]

SI: selectivity index, SI = EC50 of hemolytic activity on HRBC/MICE. coli or MIC S. aureus. ND means no data; -: the hemolytic activity was too low to calculate the EC50. /: the value of SI is unpredictable.