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. 2023 Oct 17;11(10):1604. doi: 10.3390/vaccines11101604

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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γδ T cells in the circulation after IV BCG vaccination. (a) Outline of the experimental study design. (b) Gating strategy of Vδ2+ (Vy9+) and Vδ1+ T cells from live CD3+ lymphocytes. (c) The proportion of Vδ2 and Vδ1 cells within the CD3+ population in the circulation 4, 6, 8 and 12 weeks after IV BCG vaccination. Data points represent individual animals. Asterisks represent significant differences between indicated timepoints, determined with Wilcoxon tests (p < 0.05). Correlations between Vδ2+ (d) proportions in the circulation and TB disease and health outcomes were carried out using Spearman correlation tests, with the r and p-value shown.